Cellular Nutrition & Methyl Detox

Cellular Nutrition Assay:

Cellular testing for nutrient sufficiency, antioxidant capacity, and specific protective antioxidants

Metabolism happens within cells. Cells need nutrients to be metabolically active.

• The Cellular Micronutrient Assay (CMA) is your tool to assess and address insufficiencies in micronutrients (vitamins and minerals) as well as amino acids, and other nutrients within immune cells. This is a reflection of long-term nutrient status not just a “snapshot” as is seen in serum nutrient tests.

An overload and accumulation of free radicals (from pollution, toxins, medication, radiation, etc) in the body can result in oxidative damage which plays a major role in the development of chronic and degenerative illness. Antioxidants can help protect the cells from oxidative damage.

• The Redox Assay measures the overall antioxidant function of your patients’ immune cells.
• The Antioxidant Protection Assay (APA) identifies specific antioxidants that significantly improve your patients’ antioxidant capacity and protect their cells from oxidative damage.

 Nutrient requirements are unique to each patient

• Women’s health- fertility, pregnancy, lactation, perimenopause, menopause, and others
• High performance and/or severe stress
• Sports nutrition
• Pre and post -surgery
• Weight management, obesity
• Burnout, fatigue, depression, mood swings, low vitality
• Chronic conditions, and/or metabolic syndrome (increased blood pressure and blood sugar, excess body fat, abnormal cholesterol)
• Nutritional and health status optimization

Test results

Easy to understand, color-coded test results show “nutrient sufficiency,” “borderline insufficiency,” and “insufficiency”. The function and dietary sources of each insufficient and borderline insufficient nutrient are described within the test results’ commentaries.

Methyl Detox:

More than 50% of people are affected by genetic variants in the methylation pathway.

Methylation can play an important role in many chronic diseases. By understanding your genetics you can prevent and address these conditions with the right nutrition.

The MethylDetox Profile tests critical genes in the methylation pathway. By understanding your genes and how they impact methylation, you may prevent and address existing health problems with the right nutrition.

Comprehensive testing for methylation and detoxification

The MethylDetox Profile gives more actionable information than MTHFR testing alone, giving you a more complete picture of your body’s methylation and detoxification. The MethylDetox profile includes suggestions for specific nutrient needs to address with practitioner guidance.

Standard MTHFR genotyping only evaluates folic acid metabolism. Scientific research reveals that a variety of genes are involved in maintaining methionine/homocysteine balance. Genetic variations (SNPs) in these important genes influence your methylation potential. Individual methylation is monitored using homocysteine levels. Important SNPs are included to evaluate your ability to methylate neurotransmitters, DNA, and toxins.

Who may benefit from this test?

Individuals with any of the following diagnoses or symptoms:

• Cardiovascular Diseases e.g. hypertension, coronary artery disease, stroke ^4-10
• Neurological Disorders e.g. depression, dementia, Alzheimer’s disease, ADD/ADHD, ASD, chronic fatigue syndrome, migraine, insomnia ^{7, 10-17}
• Metabolic Conditions e.g. metabolic syndrome, diabetes mellitus, kidney diseases, reduced ability to metabolize medications, multiple chemical sensitivity ^{10, 18-21}
• Musculoskeletal Disorders e.g. osteoporosis ^{10, 22}
• Eye Diseases e.g. macular degeneration ^{23, 24}
• Cancer e.g. colorectal, breast, and others ^{1, 10, 25}

Test components

1. MTHFR

The MTHFR gene’s purpose is to produce the important MTHFR enzyme in the body. This enzyme is an important part of maintaining optimal health. If the MTHFR gene has a variant, folate metabolism can be negatively impacted. Improper folate metabolism is implicated in many different diseases. ^{5, 6, 10, 26-29}

2. MTR

MTR codes for the enzyme, methionine synthase (MS). MS converts homocysteine to methionine using methylated vitamin B12. variants in this gene significantly impact homocysteine metabolism, which can increase the risk for a number of chronic conditions such as cardiovascular diseases, metabolic and neurological conditions and certain cancers. ³⁰

3. MTRR

The MTRR gene codes for the important enzyme, methionine synthase reductase (MSR). Methionine synthase reductase is required for the proper function of methionine synthase (see MTR). Both genes act together to convert homocysteine to methionine. variants can be involved with the development of cancers, Parkinson’s disease, depression, hypertension and many others. ^31-36

4. COMT

COMT is the major gene involved in methylation. It plays an important role in a variety of disorders, including estrogen-induced cancers, Parkinson’s disease, depression, hypertension and many others. COMT is also necessary for maintaining the proper balance of neurotransmitters with SAMe obtained from methionine. Genetic variants in COMT can result in various neurological problems and has also been associated with Autism. ^31-36

5. AHCY

AHCY is the only enzyme known to convert S-Adenosylhomocysteine (AdoHcy) to homocysteine. It is crucial that AHCY immediately converts AdoHcy to homocysteine and adenine in order to maintain optimal methylation potential. Studies show a link between variants in this gene with poor methylation potential and severe myopathies, developmental delays and hypermethioninemia.

6. Homocysteine

Homocysteine is an amino acid that is involved in maintaining the methionine cycle. Elevated homocysteine levels are well known risk factors for chronic disease, particularly cardiovascular, diabetes and neurodegenerative disorders ^{7, 10, 37}

Test results

Test results include suggestions from clinicians and scientists for specific nutrient needs to address with practitioner guidance.

How it works: X Factor Labs Test protocol

According to the test you order, a test specific test kit will be sent to you with instructions. Some tests require blood draws, which can be done locally at a qualified clinic or blood station. Some of the genetic tests require a simple cheek swab or buccal smear which can be done at home.

About our lab partner

MethylDetox tests are done exclusively by our lab partner Cell Science Systems, Corp. a specialty clinical laboratory that develops and performs laboratory testing in immunology and cell biology supporting the personalized treatment and prevention of chronic disease. Cell Science Systems, Corp. operates a CLIA certified laboratory and is an FDA inspected and registered, cGMP medical device manufacturer meeting ISO EN13485 2012 standards. ^{3, 17-19}

Committed to quality

Cell Science Systems fulfills high quality standards in accordance with state, federal and international regulations.

• CLIA-ID#10D0283906
• CE Marked. TUV Certified and safety monitored
• Supported by the EU and the State of Brandenburg
• ISO 13485:2003 + AC:2012